中风引起的快速肠道菌群失衡会反过

Rapidgutdysbiosisinducedbystrokeexacerbatesbraininfarctioninturn.

中风引起的快速肠道菌群失衡会反过来加重脑梗塞

Abstract

Strokeisaleadingcauseofdeathanddisabilityworldwide.Neuroprotectiveapproacheshavefailedinclinicaltrials,thuswarrantingtherapeuticinnovationswithalternativetargets.Thegutmicrobiotaisanimportantcontributortomanyriskfactorsforstroke.However,thebidirectionalinteractionsbetweenstrokeandgutmicrobiotaremainlargelyunknown.Weperformedtwoclinicalcohortstudiestocapturethegutdysbiosisdynamicsafterstrokeandtheirrelationshipwithstrokeprognosis.Then,weusedamiddlecerebralarteryocclusionmodeltoexploregutdysbiosispost-strokeinmiceandaddressthecausativerelationshipbetweenacuteischaemicstrokeandgutdysbiosis.Finally,wetestedwhetheraminoguanidine,superoxidedismutaseandtungstatecanalleviatepost-strokebraininfarctionbyrestoringgutdysbiosis.

中风是全球范围内引起死亡和致残的主要原因。由于对其进行神经保护方法在临床试验中失败，因此我们需要在治疗靶点方面进行创新。肠道菌群是众多引发中风的危险因素中重要因素。然而，我们仍不清楚中风和肠道菌群之间如何进行双向相互作用。我们进行了两项临床队列研究，以探究中风后肠道菌群失调的动态变化及其与中风预后的关系。然后，我们通过大脑中动脉闭塞模型研究了小鼠中风后肠道菌群失调情况，并探讨了急性缺血性中风与肠道菌群失调之间的因果关系。最后，我们检验了是否可以通过氨基胍、抗氧化酶和钨酸盐恢复肠道菌群平衡来缓解中风后脑梗塞。

Brainischaemiarapidlyinducedintestinalischaemiaandproducedexcessivenitratethroughfreeradicalreactions,resultingingutdysbiosiswithEnterobacteriaceaeexpansion.Enterobacteriaceaeenrichmentexacerbatedbraininfarctionbyenhancingsystemicinflammationandisanindependentriskfactorfortheprimarypoorout

转载请注明：http://www.nzjgr.com/jbby/12299.html